Almost most of the patients with treatment-refractory skin disorder-like perioral dermatitis, all had been using perioral dermatitis toothpaste which contains fluoride. When these patients were changed to non-fluoridated perioral dermatitis toothpaste, about one half had a clearance of their wounds within two to four weeks. The non-responders then changed from their existing perioral dermatitis toothpaste, which contained clearing up and seasoning agents and other strange chemicals, to baking soda and a commercial usable gargle after brushing. Just about all of these patients had nearly all over clearing of their wounds. Patients who summed up fluoride perioral dermatitis toothpaste invariably had a return of the dermatitis. Some of the patients who took this toothpaste also stated that the side on which they had the most serious dermatitis was the side on which they normally slept. That observation abides the hypothesis that nocturnal salivary drain of chemicals onto the affected areas of skin aggravates the wounds.
Perioral dermatitis affects up to some of the population, and it is prevailing amidst women than among men. It is qualified by chronic papulopustular wounds around the mouth that looks like rosacea. Perioral dermatitis was first discovered in 1957, round the time that fluoridated toothpaste was brought in the United States. In 1967, the German literature distinguished perioral dermatitis as a "new entry." The retarded acknowledgement of this condition in Germany may have been associated to the later marketing of fluoridated toothpaste in that country. The results of the present study suggest that sensitivity to fluoride or to other components in toothpaste is the most significant cause of perioral dermatitis. One can also choose natural remedies for perioral dermatitis.
Cinnamic aldehyd: Most of the doctors suggest their patients who have allergic reaction to cinnamic aldehyde in toothpaste should go for Colgate's Simply White spearmint toothpaste, which does not have the sensibilizing component. Its elemental flavorants are levomenthol and spearmint oil. The Colgate toothpaste product is more widely usable than some antecedently available toothpaste that missed cinnamic aldehyde and was got only at health food stores.
Benzophenone: Most of the patients who may have allergic reaction to toothpaste lack the full pattern of photoallergic contact dermatitis since they do not use fluoride free toothpaste. These patients may have perioral ACD even if they only utilize a lip cosmetic with sunscreen. Benzophenones also are commonly present in many products also in hair care products also, so patients may have dermatitis in regions of run-off exposed to the sun, such as the neck.